主观性耳鸣情绪障碍的多模态磁共振成像

Multimodal magnetic resonance imaging of subjective tinnitus related mood disorder

主观性耳鸣是指在没有外部声音刺激下患者主观的声音感知。耳鸣患者常伴有情绪障碍,如抑郁、焦虑等,患者的生活质量受到严重影响。因此,了解耳鸣情绪障碍的发生机制有助于缓解患者耳鸣痛苦。耳鸣在早期被认为是一种单纯的耳科疾病,但随着神经成像技术的进步和动物模型的发展,耳鸣患者神经结构和功能的改变越来越受到重视。多模态磁共振作为活体探究脑内神经活动的有力技术,在主观性耳鸣神经机制的研究中应用广泛,通过观察主观性耳鸣患者大脑中枢结构的改变,探究耳鸣发生发展的神经中枢机制。文章回顾近年来有关耳鸣情绪障碍神经机制的多模态磁共振成像研究,对比主观性耳鸣患者和健康人群的神经活动差异,发现边缘系统、默认网络等神经网络异常与耳鸣患者情绪障碍密切相关,并探讨了各种多模态磁共振技术在主观性耳鸣中的应用与发展,以期在多模态磁共振技术的帮助下阐明主观性耳鸣伴发情绪障碍的神经机制。

Subjective tinnitus refers to the subjective sound perception of patients in the absence of an external sound stimulus.Tinnitus patients are often accompanied by emotional disorders,such as depression and anxiety,which seriously affect the quality of life of patients.Therefore,understanding the mechanism underlying the occurrence of tinnitus emotional disorders can help relieve the pain of tinnitus.Tinnitus was considered a simple ear disease in the early stages,but with the progress of neuroimaging technology and the development of animal models,increasing attention has been given to the changes in the neural structure and function of tinnitus patients.As a powerful technique for in vivo investigation of neural activity in the brain,multimodal magnetic resonance has been widely used in the study of subjective tinnitus.By observing the changes of brain structure in subjective tinnitus patients,the neural mechanism of the occurrence and development of tinnitus has been explored.This article reviewed recent multimodal magnetic resonance imaging studies on the neuroimaging mechanisms of tinnitus with mood disorders,compared the differences in neural activity between subjective tinnitus patients and healthy people,and found that the limbic system,default mode network and other neural network abnormalities were closely related to the mood disorders of tinnitus.The application and development of multimodal magnetic resonance techniques in subjective tinnitus were also discussed to elucidate the neural mechanism of subjective tinnitus accompanied by mood disorders with the help of multimodal magnetic resonance techniques.