2015年—2022年衢州市2型糖尿病伴高尿酸血症监测分析

Monitoring and analysis of type 2 diabetes mellitus with hyperuricemia in Quzhou City from 2015 to 2022

目的 分析2015年—2022年衢州市2型糖尿病伴高尿酸血症(HUA)患病率及影响因素。方法 采用随机整群抽样原则,调查衢州市6个区、17个街道、92个社区居委会确诊为2型糖尿病的患者,共纳入868例。根据有无HUA分为正常尿酸组和HUA组,其中正常尿酸组719例,HUA组149例。收集2组患者一般资料及实验室指标,采用Pearson相关分析血尿酸与临床指标的相关性,多因素logistic回归分析影响2型糖尿病患者并发HUA的危险因素。结果 本研究共纳入2型糖尿病患者868例,合并HUA的患者有149例,HUA检出率为17.17%。HUA检出率在女性2型糖尿病患者中明显高于男性,差异具有统计学意义(P<0.05),且随着2型糖尿病患者年龄及病程的增加,HUA检出率逐渐增加,在各组间比较差异具有统计学意义(P<0.05)。HUA组患者年龄、BMI、尿酸、合并糖尿病肾病、收缩压、舒张压、TC、TG、FIB、BUN、FINS、SCr、CRP、UMA、UACR明显高于正常尿酸组(P<0.05),HUA患者空腹血糖、HbA_(lc)水平明显低于正常尿酸组,差异具有统计学意义(P<0.05)。血尿酸与年龄、BMI、FIB、BUN、FINS、SCr、CRP、UMA、UACR均成正相关关系(P<0.05),与空腹血糖、HbA_(lc)水平成负相关关系(P<0.05)。多因素logistic回归分析显示年龄、BMI、合并糖尿病肾病、TG、SCr水平为影响2型糖尿病并发HUA的危险因素(P<0.05),空腹血糖、HbA_(lc)为2型糖尿病并发HUA的保护因素(P<0.05)。结论 2015年—2022年衢州市2型糖尿病患者中,HUA检出率为17.17%,其中BMI、合并糖尿病肾病、TG、SCr水平为影响2型糖尿病并发HUA的危险因素,空腹血糖、HbA_(lc)为2型糖尿病并发HUA的保护因素。

Objective This paper aims to analyze the prevalence and influencing factors of type 2 diabetes mellitus with hyperuricemia(HUA) in Quzhou City from 2015 to 2022.Methods A total of 868 patients diagnosed with type 2 diabetes in 6 districts,17 streets and 92 communities of Quzhou City were investigated by random cluster sampling.According to the presence or absence of HUA,they were divided into normal uric acid group(n=719) and HUA group(n=149).Pearson correlation analysis was used to analyze the correlation between serum uric acid and clinical indicators.Multivariate logistic regression analysis was used to analyze the risk factors of HUA in patients with type 2 diabetes.Results A total of 868 patients with type 2 diabetes mellitus were included in this study,of which 149 patients were diabetes combined with HUA,and the detection rate of HUA was 17.17%.The detection rate of HUA in female patients with type 2 diabetes was significantly higher than that in male patients(P<0.05).With the increase of age and course in patients with type 2 diabetes,the detection rate of HUA increased gradually,and the difference was statistically significant among the groups(P<0.05).Age,BMI,uric acid,diabetic nephropathy,systolic blood pressure,diastolic blood pressure,TC,TG,FIB,BUN,FINS,SCr,CRP,UMA,UACR of HUA group were significantly higher than those of normal uric acid group(P<0.05),and the levels of fasting blood glucose and HbA_(lc) of HUA group were significantly lower than those of normal uric acid group,with the differences statistically significant(P<0.05).Serum uric acid was positively correlated with age,BMI,FIB,BUN,FINS,SCr,CRP,UMA and UACR(P<0.05),and negatively correlated with fasting blood glucose and HbA_(lc)(P<0.05).Multivariate logistic regression analysis showed that age,BMI,diabetic nephropathy,TG and SCr levels are risk factors for type 2 diabetes complicated with HUA(P<0.05),and fasting blood glucose and HbA_(lc) are protective factors for type 2 diabetes complicated with HUA(P<0.05).Conclusion The detection rate of HUA in patients with type 2 diabetes mellitus in Quzhou City from 2015 to 2022 is 17.17%.BMI,diabetic nephropathy,TG and SCr levels are the risk factors of type 2 diabetes mellitus complicated with HUA,and fasting blood glucose and HbA_(lc) are the protective factors.