具有NIR-Ⅱ吸收的碳包覆磁铁矿纳米团簇用于成像引导的光热-化学动力学协同治疗

Carbon-coated magnetite nanoclusters with NIR-Ⅱabsorbance for imaging-guided photothermal-chemodynamic synergistic therapy

化学动力学疗法(CDT)是基于磁铁矿纳米酶治疗癌症的新兴治疗方式.但是,它的低催化能力和单模治疗限制了其治疗功效.本工作中,我们开发了一种在第二近红外(NIR-Ⅱ)窗口中具有高吸光度的碳涂覆的磁铁矿纳米团簇(CCMNCs),用于NIR-Ⅱ光热增强的化学动力抗癌疗法.这种尺寸约58 nm的CCMNCs通过使用二茂铁作为单一前体的一步溶剂热法合成.CCMNCs不仅用作肿瘤靶向磁共振成像的造影剂,而且还吸收并将NIR-Ⅱ辐射转化为局部热量,用于高温杀死癌细胞.CCMNCs在酸溶液中产生的亚铁离子和铁离子催化Fenton反应生成CDT的羟基自由基(·OH),并减少作为自由基清除剂的细胞内谷胱甘肽.本文报道的CCMNCs通过组合的化学动力学光热处理的协同效应显示出优异的治疗功效.

Chemodynamic therapy(CDT)is an emerging therapeutic modality to treat cancer based on magnetite nanozymes.However,the low catalytic capacity and single-mode treatment limit its therapeutic efficacy.Herein,a kind of carbon-coated magnetite nanoclusters(CCMNCs)with high absorbance in the second near-infrared(NIR-Ⅱ)window has been developed for NIR-Ⅱphotothermal-enhanced chemodynamic anti-cancer therapy.Such CCMNCs with a size of about 58 nm were synthesized by a one-step solvothermal method using ferrocene as a single precursor.The CCMNCs not only serve as a contrast agent for tumor-targeted magnetic resonance imaging,but also absorb and convert NIR-Ⅱirradiation into local heat for the hyperthermic killing of cancer cells.The ferrous and iron ions produced from the CCMNCs in acid solution catalyze the Fenton reaction to generate hydroxyl radicals(·OH)for CDT and reduce the intracellular glutathione that exerts as free radical scavengers.The reported CCMNCs demonstrate a superior therapeutic efficacy through the synergistic effect of a combined chemodynamic-photothermal treatment.