基于MoS_(2)场效应晶体管的生物传感器用于无标记检测

MoS_(2) field-effect transistor-based biosensor for label-free detection

场效应晶体管(FET)由于其响应快、灵敏度高、成本低等优点而受到广泛关注。在本文中我们制备了一种基于MoS_(2)纳米片的高灵敏度FET生物传感器,并探讨了其在牛血清白蛋白(BSA)检测中的应用。BSA与MoS_(2)通过疏水相互作用直接结合。该器件对BSA的检测极限为5 nM,并且对5nM至5μM范围内的BSA溶液均有较大的电流响应。通过对器件转移特性曲线和MoS_(2)拉曼光谱的分析,我们将源漏电流(I ds)的增加归因于BSA对MoS_(2)的n型掺杂。此外,MoS_(2) FETs可以扩展为一个通用的生物传感器平台,用于各种生物分子的灵敏检测,并有望应用于高度集成和多路复用的FET传感器结构。

Field-effect transistor(FET)has been widely concerned due to their advantages of fast response,high sensitivity and low cost.Here we fabricate a highly sensitive FET biosensor based on MoS_(2) nanosheets and explore its application for the detection of bovine serum albumin(BSA).Through hydrophobic interaction,BSA is directly combined with MoS 2.The device has a detection limit of 5nM and a large current response to BSA solution in the range of 5nM to 5μM.In addition,by analyzing the transfer characteristic curve of the device and the Raman spectrum of MoS_(2),we have demonstrated that the reason for the increase of the drain-source current(I ds)is the n-type doping phenomenon of BSA on MoS_(2).We believe that the MoS_(2) FETs can be expanded into a universal biosensor platform for the sensitive detection of various biomolecules and are expected to be applied to the highly integrated and multiplexed FETs sensor structure.