CEA和幽门螺杆菌抗体分型检测与胃癌患者病理特征及预后的关系

Correlation of CEA and Helicobacter Pylori Antibody Typing with Pathological Features and Prognosis in Patients with Gastric Cancer

目的探讨癌胚抗原(CEA)和幽门螺杆菌(Hp)抗体分型检测与胃癌患者病理特征及预后的关系。方法选择2019年12月—2021年1月收治的胃癌53例设为胃癌组,均已接受手术治疗。另选取同期健康体检人群59例设为健康体检组。比较2组CEA和Hp抗体分型表达情况,分析胃癌组CEA和Hp抗体分型表达与病理特征的关系;统计胃癌患者术后1年的预后情况,采用多因素Logistic回归分析探讨影响胃癌患者预后的危险因素。结果胃癌组CEA和Hp抗体分型阳性率[(83.02%(44/53)和79.25%(42/53)]高于健康体检组[6.78%(4/59)和27.12%(16/59)](P<0.01)。CEA和Hp抗体分型表达在不同疾病分期、分化程度、浸润深度、淋巴结转移胃癌患者中比较差异有统计学意义(P<0.05,P<0.01)。疾病分期、分化程度、浸润深度、淋巴结转移、CEA和Hp抗体分型表达是影响胃癌患者预后的独立危险因素(P<0.05)。结论CEA和Hp抗体分型与胃癌患者的病理特征具有相关性,参与了该病的发生和发展,也是影响患者预后的独立危险因素,可以作为诊断胃癌和评估病情严重程度的指标。

Objective To explore the relationship of carcinoembryonic antigen(CEA)and Helicobacter pylori(Hp)antibody typing with the pathological characteristics and prognosis of patients with gastric cancer.Methods A total of 53 patients with gastric cancer admitted from December 2019 to January 2021 were selected as the gastric cancer group,all of whom had received surgical treatment.In addition,59 healthy people undergoing physical examination during the same period were selected as the health examination group.The expression of CEA and Hp antibody typing in the two groups was compared,and the relationship between the expression of CEA and Hp antibody typing and pathological characteristics in the gastric cancer group was analyzed.The prognosis of patients with gastric cancer at 1 year after surgery was analyzed and the risk factors affecting the prognosis of patients with gastric cancer were discussed by multivariate Logistic regression analysis.Results The positive rate of CEA and Hp antibody typing in gastric cancer group[83.02%(44/53)and 79.25%(42/53)]was higher than that in health examination group[6.78%(4/59)and 27.12%(16/59)](P<0.01).There were statistically significant differences in CEA and Hp antibody typing expression among patients with gastric cancer with different disease stages,degrees of differentiation,depth of invasion and lymph node metastasis(P<0.05,P<0.01).Disease stage,degree of differentiation,depth of invasion,lymph node metastasis,CEA and Hp antibody typing were independent risk factors affecting the prognosis of gastric cancer patients(P<0.05).Conclusion CEA and Hp antibody typing are correlated with the pathological characteristics of patients with gastric cancer,which participate in the occurrence and development of the disease.They are also independent risk factors affecting the prognosis of patients,and can be used as indicators to diagnose gastric cancer and assess the severity of the disease.