自拟补气通络方联合吡非尼酮治疗特发性肺纤维化患者效果及对血清炎性因子、肺功能影响

Effect of Self-designed Buqitongluo Prescription Combined with Pirfenidone on Patients with Idiopathic Pulmonary Fibrosis and Its Effect on Serum Inflammatory Factors and Pulmonary Function

目的探讨自拟补气通络方联合吡非尼酮治疗特发性肺纤维化(IPF)患者效果及对血清炎性因子和肺功能影响。方法选取2018年1月—2022年6月收治的IPF 110例,根据治疗方法不同将其分为观察组和对照组2组各55例。观察组给予自拟补气通络方联合吡非尼酮治疗,对照组给予吡非尼酮治疗。比较2组治疗后临床效果,治疗前后血清炎性因子、转化生长因子-β1(TGF-β1)、肺功能指标和血气分析指标,以及治疗期间不良反应。结果治疗后,观察组总有效率(90.91%,50/55)高于对照组(76.36%,42/55)(P<0.05)。治疗后,血清炎性因子、TGF-β1和二氧化碳分压2组均低于治疗前,且观察组低于对照组;肺功能指标及氧分压2组均高于治疗前,且观察组高于对照组(P<0.05)。治疗期间,观察组不良反应总发生率低于对照组(P<0.05)。结论自拟补气通络方联合吡非尼酮治疗IPF患者临床效果较好,可降低血清炎性因子水平,改善肺功能和血气分析指标,且安全性较好。

Objective To explore the effect of self-designed Buqitongluo prescription combined with Pirfenidone on patients with idiopathic pulmonary fibrosis(IPF)and its effect on serum inflammatory factors and pulmonary function.Methods A total of 110 patients with IPF treated from January 2018 to June 2022 were selected and divided into observation group(n=55)and control group(n=55)according to different treatment methods.The observation group was given self-designed Buqitongluo prescription combined with Pirfenidone,and the control group was given Pirfenidone.The clinical effects,serum inflammatory factors,transforming growth factor-β1(TGF-β1),pulmonary function indexes and blood gas analysis indexes before and after treatment,and adverse reactions during treatment were compared between the two groups.Results After treatment,the total effective rate of observation group(90.91%,50/55)was higher than that of control group(76.36%,42/55)(P<0.05).After treatment,serum inflammatory factor,TGF-β1 and partial pressure of carbon dioxide in the two groups were lower than those before treatment,and lower in observation group than in control group.The pulmonary function indexes and oxygen partial pressure in the two groups were higher than those before treatment,and higher in the observation group than in the control group(P<0.05).During treatment,the total incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion The self-designed Buqitongluo prescription combined with Pirfenidone has good clinical effect in the treatment of IPF patients,which can reduce the level of serum inflammatory factors,improve pulmonary function and blood gas analysis indexes,and has good safety.