内吞体运输必需分选复合物在肿瘤中的作用

The role of endosomal sorting complex required for transport in tumorigenesis

内吞体运输必需分选复合物(endosomal sorting complex required for transport,ESCRT)是与膜重塑密切相关的复合物,在许多涉及膜重塑事件中起重要作用,包括病毒出芽、细胞分裂、神经元修剪、多泡体形成等。ESCRT含多种亚基,不同亚基相互配合协同完成复合物的生物学功能。ESCRT突变或表达水平改变会引起严重后果,造成多种与膜修复相关的生物学过程出现障碍,涉及帕金森病、艾滋病、肿瘤等疾病。肿瘤发生发展与许多膜重塑事件有关,随着对ESCRT的深入研究,发现其在肿瘤发生发展、治疗及预后中起重要作用。本文主要围绕ESCRT在肿瘤中的不同作用展开综述,包括作用机制、预后评估、治疗靶点的选择等,旨在为ESCRT与肿瘤之间的关系提供思路,为多种肿瘤治疗提供更多选择。

The endosomal sorting complex required for transport(ESCRT)plays an important role in several events involving membrane remodeling,including viral budding,cell division,neuronal pruning,and multivesicular body formation.ESCRT contains different subunits working cooperatively to carry out its biological function.ESCRT mutations or changes in its expression level may cause damage to membrane repair-related biological processes,leading to disorders such as Parkinson’s disease,AIDS,or tumors.Tumorigenesis is related to several membrane remodeling events;moreover,ESCRT has been shown to play an important role in tumor occurrence,development,treatment,and prognosis.This review mainly focuses on the different roles of ESCRT in tumorigenesis,including the mechanism of action,prognosis assessment,and selection of therapeutic targets.Further,it aims to provide insight into the relationship between ESCRT and tumors and suggest more options for tumor treatment.