基于微生物-肠-脑轴探索神经递质在脑恶性肿瘤中的研究进展

Research progress on neurotransmitters in malignant brain tumors based on microbiotagut-brain axis

微生物-肠-脑轴(microbiota-gut-brain axis,MGBA)是由神经、内分泌和免疫系统相互作用而构成的复杂网络,为揭示肠道菌群如何影响脑恶性肿瘤的生物学特性提供了关键的理论框架。然而,目前多数研究倾向于探索菌群通过免疫系统对脑肿瘤的影响,而忽视了MGBA组成的多元性。本文重新审视了MGBA理论,重点关注肠道菌群对脑内神经递质(如多巴胺、5-羟色胺和谷氨酸等)的影响,并深入分析上述神经递质调控肿瘤细胞生长和侵袭的机制。旨在深化对肠道菌群与脑恶性肿瘤间关系的理解,并为未来相关领域的基础及临床研究提供新的思路与方向。

The microbiota-gut-brain axis(MGBA)constitutes a complex network through the interconnected mechanisms of the neurological,endocrine,and immune systems.MGBA has been established as a vital theoretical framework to elucidate the impact of gut microbiota on the biological characteristics of malignant brain tumors.A significant portion of existing research explores the influence of microbiota on brain tumors through the immunological pathway,thereby overlooking the intricate composition of the MGBA.Our study revisits the MGBA paradigm with an emphasis on the modulatory role of gut microbiota on cerebral neurotransmitters,including dopamine,serotonin,and glutamate.Moreover,we further analyzed their subsequent regulation of tumor cell proliferation and invasion.Furthermore,the investigation aims to enhance our knowledge of how gut microbiota may modulate the progression of malignant brain tumors,thus presenting innovative perspectives and directions for basic and clinical oncology research in the future.