上皮间质转化在卵巢癌耐药中的作用及中药干预研究进展

Research progress on epithelial⁃mesenchymal transition in drug resistance of ovarian cancer and intervention of traditional Chinese medicine

综述靶向上皮间质转化(EMT)与卵巢癌耐药相关性及中药干预研究进展。近年来,越来越多的研究报道EMT与卵巢癌的耐药密切相关,其相关机制主要涉及信号通路、外泌体、微小核糖核酸(miRNA)、长链非编码核酸(lncRNA)、免疫等。一些中药及其有效成分具有抗肿瘤作用,且在干预EMT引起的卵巢癌耐药中取得良好效果,具有潜在的应用价值。

Research progress on epithelial-mesenchymal transition(EMT)in drug resistance of ovarian cancer and intervention of traditional Chinese medicine was reviewed.In recent years,more and more studies have reported that EMT closely related to drug resistance in ovarian cancer,and its related mechanisms mainly involve signaling pathways,exosomes,miRNA,lncRNA,immunity and so on.Some traditional Chinese medicines and their active ingredients play anti-tumor effects and a good ameliorating role in intervening the drug resistance of ovarian cancer caused by EMT,which has potential application value.