新疆老年住院病人25羟维生素D及同型半胱氨酸与衰弱的相关性研究

Correlation of 25-hydroxyvitamin D and homocysteine with frailty in elderly hospitalized patients in Xinjiang

目的 探讨老年住院病人血清25羟维生素D[25(OH)D]及同型半胱氨酸(Hcy)与衰弱的相关性。方法 选取2022年1~6月在新疆维吾尔自治区人民医院老年医学中心住院的老年病人130例为研究对象,收集相关临床资料。根据Fried量表评分将病人分为无衰弱组、衰弱前期组、衰弱组,比较3组间临床资料的差异。采用Spearman秩相关分析评估各指标与衰弱程度的相关性,将衰弱前期和衰弱病人合并为衰弱组,采用二元Logistic回归分析老年住院病人发生衰弱的相关因素。结果 不同衰弱分组病人年龄,血红蛋白、Hcy、25(OH)D水平以及共病比例比较,差异均有统计学意义(P<0.05)。Fried衰弱得分与年龄、用药种类、疾病种类、Hcy水平呈正相关(P<0.05),与25(OH)D呈负相关(P<0.05)。二元Logistic回归分析显示,25(OH)D(OR=0.541;95%CI:0.373~0.786)、Hcy(OR=1.694;95%CI:1.155~2.485)与衰弱独立相关。结论 25(OH)D、Hcy与老年衰弱独立相关,25(OH)D是衰弱的保护性因素,Hcy是衰弱的危险性因素。

Objective To investigate the correlation of 25 hydroxyvitamin D [25(OH)D] and homocysteine(Hcy) with frailty in the elderly hospitalized patients.Methods A total of 130 hospitalized elderly patients in Department of Geriatric Center of Xinjiang Uygur Autonomous Region People's Hospital from January to June 2022 were enrolled in this study.According to the score of Fried Scale,all patients were divided into non-frailty group,pre-frailty group and frailty group.The clinical data were collected and compared among the three groups.Spearman rank correlation analysis was used to evaluate the correlation between each index and frailty degree.And binary Logistic regression was used to analyze the risk factors of frailty in the elderly hospitalized patients.Results There were significant differences in age,the levels of hemoglobin,Hcy,25(OH)D,and the rate of comorbidities among the three groups(P<0.05).Frailty score was positively correlated with age,the number of combined drugs,the type of comorbidity and the level of Hcy(P<0.05),and negatively correlated with the level of 25(OH)D(P<0.05).Binary Logistic regression analysis showed that 25(OH)D(OR=0.541;95%CI:0.373-0.786) and Hcy(OR=1.694;95% CI:1.155-2.485) were independently correlated with frailty.Conclusions 25(OH)D and Hcy are independently correlated with frailty,and 25(OH)D is a protective factor of frailty,and Hcy is a risk factor of frailty.