易栓症与胎儿生长受限

Thrombophilia and fetal growth restriction

易栓症分为遗传性和获得性。遗传性易栓症增加母体静脉血栓栓塞发生风险,但目前大多数研究显示遗传性易栓症与胎儿生长受限没有明确的因果关系。获得性易栓症,包括自身免疫性疾病等与胎儿生长受限之间的相关性更为密切。易栓症患者的孕期管理应由产科、风湿免疫科、儿科等多学科团队协作完成;妊娠监测应明确是否存在胎盘功能不全和胎儿生长受限,以确定最佳分娩时机,从而降低围产期发病率和死亡率。

Thromboembolism is divided into hereditary thromboembolism and acquired thromboembolism.Hereditary thromboembolism increases the risk of maternal VTE,but most of current studies have shown that there is no clear causal relationship between hereditary thromboembolism and FGR.Acquired thromboembolism(including autoimmune diseases)is more closely related to FGR.The management of pregnancy should be completed by multidisciplinary team cooperation of obstetrics,rheumatology and immunology department,pediatrics and so on.Pregnancy monitoring should be aimed at determining placental insufficiency and fetal growth restriction to determine the optimal timing of delivery and reduce the risk of perinatal morbidity and mortality.