溶酶体、线粒体在川崎病发病机制调节性细胞死亡中的作用

The role of lysosome and mitochondria in regulatory cell death in the pathogenesis of Kawasaki disease

川崎病(KD)又称皮肤黏膜淋巴结综合征,是儿童常见的急性系统性血管炎,主要危害是导致心血管事件的发生,如冠状动脉瘤、心源性猝死和早发性心力衰竭,是目前导致儿童获得性心脏疾病的主要病因,其发病机制迄今为止尚未完全明确。目前有研究认为溶酶体、线粒体可能在KD的发病机制中发挥重要作用,其主要介导调节性细胞死亡(RCD),其中包括细胞焦亡、自噬和细胞凋亡。本文就溶酶体、线粒体在KD中3种调节性细胞死亡方式中的作用国内外研究进展综述如下。

Kawasaki disease(KD) or cutaneous mucocutaneous lymph node syndrome,is a common acute systemic vasculitis in children,which mainly leads to cardiovascular events,such as coronary artery aneurysm,sudden cardiac death and early heart failure.It is the main cause of acquired heart disease in children.So far,the pathogenesis of Kawasaki disease is not completely clear.Current studies suggest that lysosomes and mitochondria may play an important role in the pathogenesis of KD,which mainly mediates regulatory cell death(RCD),including pyroptosis,autophagy and apoptosis.This article reviews the domestic and overseasresearch progress on the role of lysosome and mitochondria in the three regulatory cell death modes of KD.