铁死亡在免疫细胞调节中的研究进展

Research progress of ferroptosis in immune cell regulation

铁死亡是由大量脂质过氧化介导的依赖铁的程序性死亡。免疫细胞可以通过清除死细胞的碎片来预防炎症和自身免疫性疾病。铁死亡与感染、炎症和肿瘤之间均存在潜在的联系。同时,免疫细胞在上述过程中起着至关重要的作用,因此探讨两者之间的关系具有重要的意义。本综述试图解释铁死亡与各种免疫细胞之间的联系,并明确铁死亡在感染、炎症和恶性肿瘤中发挥的作用,由此,可以找到这些疾病的潜在治疗靶点。

Ferroptosis is an iron dependent programmed death mediated by massive lipid peroxidation.Immune cells can prevent inflammation and autoimmune diseases by removing debris of dead cells.There are potential links between ferroptosis and infection,inflammation and tumors.At the same time,immune cells play a crucial role in the above process,so it is of great significance to explore the relationship between them.This review attempts to explain the relationship between ferroptosis and various immune cells,and clarify the role of ferroptosis in infection,inflammation and malignant tumors,so that we can find potential therapeutic targets for these diseases.