达格列净在早期2型糖尿病肾病中的应用及对肾功能的影响分析

Application of Dapagliflozin in Early Type 2 Diabetic Nephropathy and Its Influence on Renal Function

目的探讨达格列净在早期2型糖尿病肾病治疗中的临床效果及患者肾功能随治疗变化的情况。方法选取哈尔滨市第一医院肾内科2020年1月—2021年7月收治的早期2型糖尿病肾病患者106例为研究对象,采用数字标记方式分为两组,各53例。对照组单纯使用马来酸依那普利进行治疗,研究组使用马来酸依那普利联合达格列净进行治疗。比较分析组间用药前后尿微量白蛋白、胱抑素C、治疗总有效率以及药物不良反应发生情况。结果治疗后,研究组的尿微量白蛋白、胱抑素C水平均优于对照组,差异有统计学意义(P<0.05)。研究组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论达格列净在治疗2型糖尿病肾病中具有非常理想且积极的效果,其药效稳定、持久,且起效快,能有效降低患者机体尿微量白蛋白浓度,抑制胱抑素C的产生,且不良反应少,可与多种药物联合使用。

Objective To investigate the clinical effect of dapagliflozin in the treatment of early type 2 diabetic nephropathy and the changes of renal function of patients with treatment.Methods 106 patients with early type 2 diabetes nephropathy admitted to the Department of Nephrology of Harbin First Hospital from January 2020 to July 2021 were selected as the research objects.They were divided into two groups by digital labeling,53 patients in each group.The control group was treated with enalapril Maleic acid alone,while the study group was treated with enalapril Maleic acid combined with Dapagliflozin.The urinary microalbumin,Cystatin C,total effective rate and Adverse drug reaction before and after treatment were compared and analyzed between the groups.Results After treatment,the levels of urinary microalbumin and Cystatin C in the study group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The total effective rate of the research group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Dapagliflozin has a very ideal and positive effect in the treatment of type 2 diabetes nephropathy.Its efficacy is stable,lasting,and fast.It can effectively reduce the concentration of urinary microalbumin in patients,inhibit the production of Cystatin C,and has less adverse reactions.It can be used in combination with a variety of drugs.