肝癌转化治疗策略

Strategies of conversion therapy for liver carcinoma

以外科为主导的综合治疗是肝癌诊疗的重要共识。肝切除术、肝移植术是肝癌患者获得长期生存的重要手段。随着肝脏外科技术的发展,肝脏手术已无禁区。转化治疗为初始不可切除肝癌患者带来了手术根治的希望。本文对剩余肝体积不足肝癌的转化治疗、肿瘤学不可切除中晚期肝癌的降期转化治疗、转化后手术时机选择等问题进行探讨,并就形成肝癌转化治疗的规范进行展望。

Surgery-led comprehensive treatment is an important consensus in the management of liver carcinoma.Hepatectomy and liver transplantation are the most important means for patients with liver carcinoma to achieve long-term survival.With the development of liver surgery techniques,liver surgery is no longer off-limits.Translational therapy offers the hope of surgical radical treatment for patients with initially unresectable liver carcinoma.This article discusses the conversion therapy for unresectable liver carcinoma with future liver remnant surgery,the downstaging conversion therapy of oncologically unresectable intermediate to advanced liver carcinoma,the timing of surgery after conversion,and safety and efficacy.Prospect for the formation of the standardization of translational therapy for liver carcinoma is made.