摘要
胰腺导管腺癌成纤维化基质在肿瘤进展和治疗抵抗中扮演着重要角色,因此基质靶向治疗策略具有潜在的临床应用前景,相关疗法正在接受广泛的研究评估。本文主要从肿瘤相关成纤维细胞、细胞外间质和新生血管3个方面回顾胰腺导管腺癌基质靶向策略的研究进展,并对未来发展方向进行展望。
Desmoplastic stroma of pancreatic ductal adenocarcinoma plays an important role in tumor progression and treatment resistance.Stroma-targeted therapies are therefore promising for clinical application and extensive related researches are undergoing.In this article,recent advances in stromal targeting strategies were reviewed from three perspectives:cancer-associated fibroblasts,extracellular matrix and angiogenesis,and an outlook for the future of this strategy was also provided.
作者
秦涛
崔成昊
王砚伟
梁雨荣
Qin Tao;Cui Chenghao;Wang Yanwei;Liang Yurong(Department of Hepatobiliary Surgery,Affiliated Hospital of Gansu Medical College,Pingliang 744000,China;Graduate School,Medical School of Chinese PLA,Beijing 100853,China;Faculty of Hepato-Pancreato-Biliary Surgery,Chinese PLA General Hospital,Institute of Hepatobiliary Surgery of Chinese PLA,Key Laboratory of Digital Hepatobiliary Surgery of PLA,Beijing 100853,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2023年第6期476-480,共5页
Chinese Journal of Hepatobiliary Surgery
关键词
胰腺肿瘤
成纤维细胞
细胞外间质
血管新生
Pancreatic neoplasms
Fibroblasts
Extracellular matrix
Angiogenesis
