FOXO3在脑缺血中的作用

The Role of FOXO3 in Cerebral Ischemia

脑缺血是导致死亡和长期残疾的主要原因,是一个全球性的健康问题,其病因复杂,发病机制尚不明确。转录因子叉头盒蛋白O3(Forkhead box protein O3, FOXO3)经翻译后修饰(posttranslational modifications, PTMs)后,自身活性发生改变,通过对靶基因的调控,参与调节脑缺血后的凋亡、炎症、氧化应激、自噬及血脑屏障损伤。值得注意的是, FOXO3对缺血性脑损伤不但有促进作用,还具有保护作用。该文就FOXO3的结构及翻译后修饰进行简单介绍,阐述其在脑缺血中的作用,旨在为该疾病的研究提供新思路。

Cerebral ischemia is a major cause of death and long-term disability,which is a global health problem with complex etiology and unclear pathogenesis.The transcriptional factor FOXO3(Forkhead box protein O3)changes its activity after PTMs(post-translation modifications),and it is involved in the regulation of apoptosis,inflammation,oxidative stress,autophagy and blood-brain barrier after cerebral ischemia through the regulations of target genes.It is noteworthy that FOXO3 not only promotes but also protects ischemic brain injury.In this paper,the structure and post-translational modification of FOXO3 are briefly introduced,and its role in cerebral ischemia is expounded,in order to provide new ideas for the study of this disease.