埋线提升术相关并发症的meta分析

Meta-analysis of complications related to thread lift

目的探讨埋线提升术在面部年轻化治疗中相关并发症的发生率。方法检索中国知网、维普中文科技期刊全文数据库、万方数据、中国生物医学文献数据库、PubMed、Cochrane Library及Embase数据库中采用埋线提升术进行面部年轻化治疗的相关文献。各数据库检索时间均为建库至2022年4月20日。制定纳入标准和排除标准,纳入符合标准的相关研究。由2名研究者独立进行文献筛选和资料提取;采用STROBE声明中针对横断面研究的规范要求进行质量评分,总分0~22分,评分>11分认为是高质量研究。采用Stata16.0软件进行埋线提升术相关并发症发生率的meta分析。采用Egger检验及绘制漏斗图评估文献的发表偏倚。结果最终纳入33篇文献进行meta分析,包含8 919例患者。28篇文献的质量评分>11分,其余5篇均为11分,文献的整体质量尚可。meta分析中涉及的结局指标包括感觉异常、感染、面部不对称、面神经损伤、轻度凹凸不平或轮廓不规则、术后过敏、术后血肿、疼痛、线材外露或可见、淤青、肿胀等11个指标。各结局指标的并发症发生率分别为:感觉异常(1%)、感染(0)、面部不对称(2%)、面神经损伤(0)、轻度凹凸不平或轮廓不规则(7%)、术后过敏(0)、术后血肿(0)、疼痛(17%)、线材外露或可见(7%)、淤青(28%)、肿胀(55%)。Egger检验及绘制漏斗图分析显示,感觉异常、面部不对称、术后过敏及疼痛4个结局指标不存在发表偏倚,其余7个指标可能存在一定的发表偏倚。结论在埋线提升术相关并发症中,术后肿胀、疼痛和淤青最为常见,严重的术后并发症罕见,且大多数并发症是一过性和自愈性的,总体可以认为埋线提升术是一种比较安全的治疗方式。

Objective To investigate the incidence of complications related to thread lift in the treatment of facial rejuvenation.Methods The databases of China National Knowledge Infrastructure(CNKI),VIP Chinese Science and Technology Journal Full-text Database(VIP-CSJFD),Wanfang Data,China Biology Medicine(CBM),PubMed,The Cochrane Library and Embase were searched from database establishment to April 20,2022.The inclusion and exclusion criteria were developed to include relevant studies that met the criteria.Two investigators independently performed literature screening and data extraction;the STROBE statement scored the quality of inclusion criteria for cross-sectional studies,the total score was 0-22 points,and the research of which score>11 points was considered as high-quality research;data analysis was performed using Stata16.0 software;Egger test and funnel plot analysis were used to evaluate the publication bias of literature.Results Thirty-three articles involving 8919 patients were included in this meta-analysis.The quality scores of 28 articles were>11 points,and the remaining 5 articles were exactly 11 points,indicating that the overall quality of the articles was acceptable.The outcome measures of this meta-analysis included 11 indicators such as paresthesia,infection,facial asymmetry,facial nerve injury,mild unevenness or irregular contour,postoperative allergy,postoperative hematoma,pain,wire exposure or visibility,bruising,and swelling.The complication rates for each outcome measure were:paresthesia(1%),infection(0),facial asymmetry(2%),facial nerve injury(0),mild unevenness or contour irregularity(7%),postoperative allergy(0),postoperative hematoma(0),pain(17%),exposed or visible wire(7%),bruising(28%),swelling(55%).Egger test and funnel plot analysis showed that there was no publication bias in sensory abnormalities,facial asymmetry,postoperative allergy and pain.There may be some publication bias in the other 7 indicators.Conclusion Among the complications related to thread lift,postoperative swelling,pain and bruising are the most common,while the incidence of serious complications is rare.Most complications are transient and self-resolving,and in general,thread lift is a relatively safe treatment modality.