通心络联合辛伐他汀对急性心肌梗死患者的影响

Effect of Tongxinluo Combined with Simvastatin on Patients with Acute Myocardial Infarction

目的 探讨通心络联合辛伐他汀对急性心肌梗死患者Toll样受体4(TLR4)、核因子-κB(NF-κB)、肿瘤坏死因子-α(TNF-α)和血脂水平及预后的影响。方法 选择急性心肌梗死患者60例,随机分为2组,辛伐他汀组在常规治疗的基础上给以辛伐他汀治疗,通心络联合辛伐他汀组在辛伐他汀组基础上加用通心络,比较2组治疗前后TLR4、NF-κB、TNF-α、血脂水平以及预后情况。结果 治疗后,2组TLR4、NF-κB、TNF-α、TC、TG和LDL-C均下降,HDL-C升高,且通心络联合辛伐他汀组更明显(P<0.05);不良心血管事件发生率明显降低。结论 通心络联合辛伐他汀可以更好地降低急性心肌梗死患者体内的炎症反应,进一步减少不良心血管事件,此作用可能通过或部分通过改善甚至恢复HDL的心脏保护作用而实现。

Objective To explore the effects of Tongxinluo combined with simvastatin on the expressions of TLR4,NF-κB,TNF-α and blood lipids and prognosis in acute myocardial infarction(AMI).Methods 60 patients with AMI were enrolled.The patients were divided into simvastatin group and Tongxinluo combined with simvastatin group.While the Tongxinluo combined with simvastatin group was given Tongxinluo on the base of simvastatin group.The expressions of TLR4,NF-κB,TNF-α and blood lipids before and after treatment and the prognosis of the two grope was compared.Results The expression of TLR4,NF-κB,TNF-α,TG,TC and LDL-C were both decreased after treatment in two groups(P<0.05).It is decreased significantly in Tongxinluo combined with simvastatin group(P<0.05).The incidence of major adverse cardiovascular events was significantly reduced.Conclusion The combination of Tongxinluo and simvastatin can more effectively reduce inflammation,and further reduce the risk of adverse cardiovascular events.The effect may be achieved by or in part by improvement or even reversion HDL myocardial protection.