试论中药功效组学

Discussion of traditional Chinese medicine efficacy omics

从单味中药功效切入,紧扣临床用药实际,开展文献调研和相关分析,研究一药多能及其相互关系,构建中药功效组学框架体系。功效是中药固有的,也是中药中最重要、最活跃的元素,源于人们长期实践经验的总结和凝练。一药多能是中药的重要特征和普遍规律,一味中药就是一个多功效组合集群。中药各功效之间不是孤立的,而是彼此关联、相互影响的,多能整体表征而效应多元是中药的优势和特色。根据临床治疗用药的需求,可采取适当的手段或措施进行人为干预和调控,选择适宜功效,规避不适宜功效,有利于发挥中药功效之专长,提高临床精准用药的水平。加强中药功效组学研究,具有重要的理论价值和实践意义。

Using the efficacy of a single medicine as an entry point,followed by data on the actual clinical use of the medicine,a literature research and relevant analyses were performed to study the multipotency of the medicine and its interrelationships,in order to build a framework system of traditional Chinese medicine(TCM)efficacy omics.Efficacy is inherent in TCM,and it is also the most important and active element in TCM,which originates from summarizing and condensing people’s long-term practical experience.One medicine with multiple functions is an important feature and general rule of TCM,because a single medicine is a multi-potency combination cluster.The efficacy of TCM is not isolated from each other,but is interrelated and influences each other.Multifunctional overall representation with multiple efficacies is the advantage and characteristic of TCM.According to the needs of clinical therapeutic use,appropriate means or measures can be taken for human intervention to regulate suitable efficacy selection and avoid unwanted effects.This is conducive to bringing into play the expertise of the efficacy of TCM,and improving the level of clinical precision in drug use.It is of great theoretical value and practical significance to strengthen the study of TCM efficacy omics.