基于17948篇中英文文献分析近20年中医药治疗慢性肾脏病研究热点与趋势

Research hotspots and trends of traditional Chinese medicine for chronic kidney disease 2002-2022 based on 17,948 Chinese and English articles

目的对近20年公开发表的中医药治疗慢性肾脏病的相关研究进行文献计量学分析,探索该学科领域的发展现状及趋势,预测未来研究方向。方法计算机检索万方数据知识服务平台、中国国家知识基础设施、中国生物医学文献服务系统、维普网、Web of Science、Cochrane Library、PubMed、Embase数据库2002—2022年公开发表的关于中医药治疗慢性肾脏病的相关研究文献,经NoteExpress软件筛选后通过CiteSpace 5.8R3和VOSviewer软件对作者、机构、关键词进行共现、聚类及突现分析,绘制可视化知识图谱。结果共纳入文献17948篇,包括中文文献14593篇、英文文献3355篇,发文量逐年攀升,趋势稳定;核心作者884位,包括中文作者362位、英文作者522位,该领域已形成了以多个关键学者为中心的稳定团体,且各机构间合作密切;研究热点前期多集中于名医经验、临床观察、证候分析,后期多集中于多组学方式探究慢性肾脏病生理病理机制与药物作用机制,涉及基础学科与生物信息分析、数据挖掘、网络药理学等新兴学科。结论中医药治疗慢性肾脏病领域研究发展态势稳定,临床研究方向从疗效观察逐渐发展为循证级别更高的随机平行对照研究,基础研究的力度与深度伴随时间推移不断增强,其中以代谢组学为切入点,探讨中医药通过自噬调控免疫应答、内质网应激、肠黏膜屏障及肠道菌群等方面干预慢性肾脏病病理进展或是近期及未来一段时间的重点研究方向。

Objective We aimed to conduct bibliometric analysis on relevant studies published in the past 20 years on the treatment of chronic kidney disease(CKD)with traditional Chinese medicine,to explore the current situation and development trends,and predict the future research direction.Methods The relevant research literature on the treatment of CKD by traditional Chinese medicine published in the Wanfang database,CNKI,SinoMed,VIP,Web of Science,Cochrane Library,PubMed,and Embase database from 2002 to 2022 was searched.The articles were screened using NoteExpress software,and the authors,institutions,and keywords were identified by CiteSpace 5.8R3 and VOSviewer clustering and emergence analysis software,and a visual knowledge graph was drawn.Results A total of 17,948 articles were included,namely,14,593 Chinese and 3,355 English articles.The number of publications increased each year,and the trend was stable;there were 884 core authors,including 362 Chinese authors and 522 English authors.A stable group centered on a number of key scholars had been formed in this field,and there was close cooperation among institutions.In the early stage,most of the research focused on the experience of renowned practitioners,clinical observation,and syndrome analysis;and in the later stage,most of the research focused on basic disciplines,such as the physiological and pathological mechanism of CKD and the mechanism of drug action in a multi group context,as well as new emerging disciplines,such as bioinformatics analysis,data mining,and network pharmacology.Conclusion The CKD field is in a steady state of research development,and the direction of clinical development has gradually progressed from efficacy observation to more evidencebased,randomized parallel controlled studies.Basic research in terms of its strength and depth has been increasing over time,and metabolomics has been used as an entry point to explore the potential of traditional Chinese medicine to intervene in the pathological progression of CKD,through autophagy regulation of the immune response,endoplasmic reticulum stress,intestinal mucosal barrier,and intestinal flora,which are likely a key research direction in the near future.