仿生聚天冬酰胺衍生物聚合物胶粘剂的制备及其性能

Preparation and properties of biomimetic polyaspartamide derivative adhesive

用于组织固定和伤口护理的生物胶粘剂的开发仍然是一个挑战。本研究采用聚琥珀酰亚胺为基体,引入三种不同组合的多巴胺(DOPA)、乙醇胺(EA)和疏水氨基辛烷(OA),合成了聚天冬酰胺衍生物,并通过连续氨解反应分别制备了聚天冬酰胺衍生物PolyAspAm(DOPA/EA)和PolyAspAm(DOPA/OA/EA)胶粘剂。研究结果表明:(1)不同含水量的PolyAspAm(DOPA/EA)胶粘剂在玻璃基材上的拉伸剪切强度具有较大差异,且含水量降低,拉伸剪切强度变大。当PolyAspAm(DOPA/EA)胶粘剂中水分含量降低到7%时,拉伸剪切强度明显升高到0.6 MPa。(2)PolyAspAm(DOPA/OA/EA)胶粘剂在不同基材上的拉伸剪切强度均大于PolyAspAm(DOPA/EA)胶粘剂。在常用基材如玻璃、塑料基材(PMMA)和锡箔纸上,PolyAspAm(DOPA/OA/EA)胶粘剂的拉伸剪切强度可分别达到(0.36±0.032)MPa、(0.28±0.021)MPa和(0.29±0.024)MPa。(3)PolyAspAm(DOPA/OA/EA)胶粘剂具有较好的粘接稳定性,对玻璃基材应用14 d后,拉伸剪切强度达到最高值(0.65±0.029)MPa。(4)在PolyAspAm(DOPA/OA/EA)聚合物中引入物质的量为5%的高碘酸钠,可以提高胶粘剂的内聚力,对玻璃基材的拉伸剪切强度从(0.36±0.032)MPa提高到(0.51±0.039)MPa。

The development of bio-adhesive for tissue fixation and wound care still remains a challenge.In this study,three different combinations of dopamine(DOPA),ethanolamine(EA)and hydrophobic amino octane(OA)were introduced,polyaspartamide derivatives were first synthesized by using polysuccinimide as the matrix,and then polyaspartamide derivatives PolyAspAm(DOPA/EA)and PolyAspAm(DOPA/OA/EA)adhesive were prepared through continuous ammonolysis reaction.The research results showed that:(1)The tensile shear strength of PolyAspAm(DOPA/EA)adhesive with different water contents on glass substrate was quite different,and the tensile shear strength increased with the decrease of water content.When the water content of PolyAspAm(DOPA/EA) adhesive decreased to 7%,the tensile shear strength increased significantly to 0.6 MPa.(2)The tensile shearstrength of PolyAspAm(DOPA/OA/EA) adhesive on different substrates was greater than that of PolyAspAm(DOPA/EA)adhesive.On common substrates such as glass,plastic substrate(PMMA)and tin foil,the tensile shearstrength of PolyAspAm(DOPA/OA/EA)adhesive could reach(0.36±0.032)MPa,(0.28±0.021)MPa and(0.29±0.024) MPa,respectively.(3)PolyAspAm(DOPA/OA/EA) adhesive had good bonding stability. After 14 days ofapplication to glass substrate,the tensile shear strength reached the highest value as(0.65±0.029)MPa.(4)Theintroduction of 5% sodium periodate into PolyAspAm(DOPA/OA/EA)polymer could improve the cohesion of theadhesive,the tensile shear strength on glass substrate increased from(0.36±0.032)MPa to(0.51 ±0.039)MPa.