线粒体途径与癫痫发病相关性研究进展

Research progress on the correlation between mitochondrial pathway and epilepsy

癫痫是一种复杂的疾病谱系,因其长期发作而影响患者的生存和生活质量,但目前的治疗方法多数仅能控制症状而难以控制病情进展,因而对癫痫的发病机制仍需进行深入探索,以求找到合适的治疗靶点。该综述从能量耗竭、氧化应激损伤、钙稳态受损和谷氨酸释放增多、线粒体DNA突变、辅酶Q10缺乏、线粒体移动变化异常等方面对线粒体途径相关的癫痫发病机制进行了讨论并提出了相关治疗思路。本文表明线粒体功能从各种途径影响着癫痫的发作,进一步了解线粒体与癫痫发病的关系,有利于寻找新的治疗靶点,开发超越癫痫控制的新疗法。

Epilepsy is a complex disease spectrum,because of long-term recurrent seizures and seriously affect the quality of life of patients,it is of great significance to explore the pathogenesis of epilepsy and actively seek new therapeutic targets.In this paper,the pathogenesis of epilepsy related to mitochondrial pathway was discussed from the aspects of energy depletion,oxidative stress damage,impaired calcium homeostasis,increased glutamic acid release,mitochondrial DNA mutation,Coenzyme Q10 deficiency,abnormal mitochondrial movement and change,and relevant therapeutic ideas were proposed.This paper shows that mitochondrial function affects the onset of epilepsy from various ways.Further understanding of the relationship between mitochondria and the onset of epilepsy is beneficial to find new therapeutic targets and develop new therapies beyond the control of epilepsy.