中医药治疗新型冠状病毒感染文献计量学研究

Bibliometrics Study of Traditional Chinese Medicine in the Treatment of Corona Virus Disease 2019

目的为开展中医药治疗新型冠状病毒感染(简称新冠病毒感染)的临床研究提供参考。方法检索中国知网(CNKI)、万方数据库(WanFang)、维普数据库(VIP)、中国生物医学文献服务系统(SinoMed)、万方医学网,检索时限为2020年1月1日至2021年12月31日,纳入中医药治疗新冠病毒感染的临床研究类文献,统计纳入文献的基本信息、用药方案和结局指标等,随机及非随机对照研究分别采用Jadad量表和纽卡斯尔-渥太华量表(NOS)进行方法学质量评价。采用CiteSpace 5.8.R3软件分析作者、发文机构之间合作关系,并以可视化图谱形式展现。结果共纳入文献142篇,其中随机对照研究33篇。纳入文献Jadad量表评分为(2.06±1.09)分,NOS评分为(4.79±0.99)分,发文机构主要集中在湖北省,且多为医院。各文献作者及其单位之间合作较少。共涉及中药方剂182个,其中清肺排毒汤使用频次最高。结局指标中主要症状(发热、咳嗽、乏力)改善率、临床总有效率、淋巴细胞总数变化率等受关注较多。目前,中医药治疗新冠病毒感染的临床研究存在样本量小、未实施盲法、分配隐藏、随机化不合理等问题。结论中药方剂治疗新冠病毒感染重视分期论治,疗效较好,但缺乏高质量临床研究,建议进一步规范中医药临床循证研究的设计和实施。

Objective To provide a reference for the development of clinical research of traditional Chinese medicine(TCM)in the treatment of corona virus disease 2019(COVID-19).Methods The clinical researches of TCM in the treatment of COVID-19 in the CNKI,WanFang,VIP,SinoMed and WanFang Med Online from January 1,2020 to December 31,2021 were searched.Basic information,medication regimens and outcome indicators were extracted from the included studies.The Jadad Scale and the Newcastle-Ottawa Scale(NOS)were used in the randomized controlled trials(RCTs)and non-RCTs for the quality evaluation of methodology,respectively.The author cooperation and the cooperation of institutions publishing study were analyzed and visualized by the CiteSpace 5.8.R3 software.Results A total of 142 studies were included,including 33 RCTs.The Jadad Scale score of the included studies was(2.06±1.09)points,and the NOS score was(4.79±0.99)points.The institutions publishing study were mainly in Hubei province and mostly hospitals.There was less cooperation of authors in various studies,as well as their research institutions.There were a total of 182 TCM formulas involved,of which Qingfei Paidu Decoction was used the most frequently.Among the outcome indicators,the improvement rate of main symptoms(fever,cough,fatigue),total clinical effective rate,change rate of lymphocyte count received much attention.At present,the clinical researches of TCM in the treatment of COVID-19 had problems such as small sample size,not implementing blind method,unreasonable allocation concealment and randomization.Conclusion TCM in the treatment of COVID-19 emphasizes the treatment by stages,and the efficacy was good,but lack of high-quality research.It is suggested that we should further standardize the design and implementation of evidence-based clinical research on TCM.