血清sLOX-1、Visfatin水平与急性脑梗死患者预后的相关性

Correlation between serum sLOX-1,Visfatin levels and prognosis of patients with acute cerebral infarction

目的 探讨血清可溶性凝集素样氧化低密度脂蛋白受体-1 (sLOX-1)、内脂素(Visfatin)水平与急性脑梗死(ACI)患者预后的相关性。方法 选取2019年9月至2022年9月海南医学院第一附属医院神经内科收治的117例ACI患者,根据出院3个月后改良Rankin量表(mRS)评分结果分为预后良好组(81例)和预后不良组(36例)。对比两组患者临床基础资料及血清sLOX-1、Visfatin水平,采用Logistic回归分析ACI患者预后不良的危险因素。结果 随着ACI程度的加重,ACI患者血清sLOX-1、Visfatin水平显著升高(P<0.05)。预后不良组重度ACI患者比例高于预后良好组,预后不良组血sLOX-1、Visfatin水平也高于预后良好组(P<0.05)。Logistic回归分析显示,重度ACI及血sLOX-1、Visfatin水平升高是ACI患者预后不良的危险因素(P<0.05)。血清sLOX-1与Visfatin联合评估ACI患者预后不良的曲线下面积(AUC)为0.844。结论 血清sLOX-1、Visfatin水平与ACI患者的病情及预后密切相关,联合检测血清sLOX-1及Visfatin水平有助于早期判断ACI患者预后。

Objective To investigate the correlation between serum soluble lectin-like oxidized lowdensity lipoprotein receptor-1(sLOX-1)and Visfatin levels and the prognosis of patients with acute cerebral infarction(ACI).Methods A total of 117 patients with ACI in the department of neurology of the first affiliated hospital of Hainan medical college from September 2019 to September 2022 were selected and divided into a good prognosis group(81 cases)and a poor prognosis group(36 cases)according to the modified rankin scale(mRS)score at 3 months after discharge.The basic clinical data and serum levels of sLOX-1 and Visfatin were compared between the two groups.Logistic regression was used to analyze the risk factors of poor prognosis in ACI patients.Results With the aggravation of ACI,the serum levels of sLOX-1 and Visfatin in ACI patients were significantly increased(P<0.05).The proportion of patients with severe infarction in the poor prognosis group was higher than that in the good prognosis group,and the levels of sLOX-1 and Visfatin in the poor prognosis group were also higher than those in the good prognosis group(P<0.05).Logistic regression analysis showed that severe cerebral infarction and increased levels of sLOX-1 and Visfatin were risk factors for poor prognosis in ACI patients(P<0.05).The area under the curve(AUC)of serum sLOX-1 combined with Visfatin for predicting poor prognosis in ACI patients was 0.844.Conclusions Serum sLOX-1 and Visfatin levels are closely related to the condition and prognosis of patients with ACI.Combined detection of serum sLOX-1 and Visfatin levels can help to early predict the prognosis of patients with ACI.