胶带撕拉模型法在皮肤修护类化妆品功效评价中的应用

Application of tape stripping method in efficacy evaluation of skin repair cosmetics

为探讨胶带撕拉模型法在皮肤修护类化妆品功效评价的应用,选择30名合格受试者,用胶带连续粘贴撕拉法建立急性皮肤屏障损伤模型,通过仪器测量分析使用产品前后受损部位经皮失水量(TEWL)、角质层含水量(CAP)、红斑指数(EI)、皮肤泛红程度a*4个指标改善情况评估不同剂型化妆品的修护功效。结果显示,建模后TEWL、CAP、EI、a*均升高,使用测试产品后,4个指标的测试结果均有一定程度的改善,其测试结果较空白对照组均有显著性差异。在胶带撕拉建立急性皮肤屏障损伤模型条件下,经皮失水量测试、角质层含水量值测试、红斑指数测定、皮肤泛红程度是评价化妆品修护功效的有效方法。

To explore the application of tape stripping method in efficacy evaluation of skin repair cosmetics,30 qualified subjects were selected and an acute skin barrier injury model was established by continuous adhering and tearing with tape.The improvement of four indicators were measured to evaluate the repair efficacy of cosmetics of different types,namely,the transepidermal water loss(TEWL),water content in stratum corneum(CAP),erythema index(EI)and the degree of skin redness a*before and after using the products were analyzed.The results showed that TEWL,CAP,EI and a*were all increased after modeling.After using the test products,the four indicators were all improved to a certain extent,indicative of significant difference from the blank control group.Therefore,based on this acute skin barrier injury model transepidermal water loss,water content in stratum corneum,erythema index and the degree of skin redness are effective to evaluate the repair efficacy of cosmetics.