骨唾液酸蛋白在恶性肿瘤中的研究进展

Research progress of bone sialogin in malignant tumors

骨唾液酸蛋白(BSP)是由骨基质和肿瘤细胞分泌,存在于细胞外基质(ECM)中的一种非胶原磷酸化糖蛋白,通过与整合素avβ3结合,可以介导肿瘤细胞与ECM的黏附作用、促进ECM的降解、参与血管生成和体液免疫等,在恶性肿瘤增殖、侵袭和转移过程中起着关键作用,被认为是一种新的肿瘤标志物。本文概述了BSP的生物学特性及近年来BSP与恶性肿瘤的相关性研究,进而评估其在恶性肿瘤早期诊断、疗效评价和预后监测的临床意义。

Bone sialoprotein(BSP)is a non-collagenous phosphorylated glycoprotein secreted by bone matrix and tumor cells,and exists in extracellular matrix(ECM).By binding to integrin avβ3,it can mediate the adhesion between tumor cells and ECM,promote the degradation of ECM,participate in angiogenesis and humoral immunity,etc.It plays a key role in the process of malignant tumor proliferation,invasion,and metastasis,and is considered as a new tumor marker.This paper summarizes the biological characteristics of BSP and the recent studies on the correlation between BSP and malignant tumors,and evaluates the clinical significance of BSP in the early diagnosis,efficacy evaluation,and prognosis monitoring of malignant tumors.