江苏省2010与2018年居民胰腺炎疾病负担和变化趋势分析

Disease burden and changing trend of pancreatitis among residents in Jiangsu in 2010 and2018

目的分析江苏省2010、2018年居民胰腺炎疾病负担和变化趋势。方法利用全球疾病负担2019(GBD2019)研究结果,以伤残损失生命年(YLD)、早死损失生命年(YLL)、伤残调整生命年(DALY)分析2010、2018年江苏省123165例胰腺炎患者[男性79584例,女性43581例,年龄23~76(49.62±5.14)岁]的疾病负担以及变化趋势。结果2018年江苏省胰腺炎死亡人数多达3.6万,其中男性2.1万,女性1.5万,病死率高达50.00%。2010年和2018年江苏省胰腺炎DALY率(325.6%)、YLL率(26.2%)、YLD率(106.2%)变化情况均高于全球变化情况(-3.2%、-5.8%、32.6%),经年龄标准化,江苏省的标化YLD率与2010年相比,增幅高达21.6%,而全球标化YLD率下降了1.1%,江苏省与全球胰腺炎的标化YLL率均降低,且降低幅度较为接近,江苏省DALY率与2010年相比,下降了-25.4%,全球标化DALY率下降了28.6%。结论与2010年相比,2018年江苏省胰腺炎负担越来越重,并且比全球平均水平高,临床应通过多种途径进行干预,尽可能降低胰腺炎对家庭以及社会造成的负担。

Objective To analyze the disease burden and changing trend of pancreatitis among residents in Jiangsu in 2010 and 2018.Methods Using the results of the Global Burden of Disease 2019,123165 cases of pancreatitis in Jiangsu in 2010 and 2018 were analyzed by years of life lost with disability(YLD),years of premature death(YLL),and disability-adjusted life years(DALY),including 79584 males and 43581 females who were 23-76(49.62±5.14)years old.The disease burden and changing trends in the patients were analyzed.Results The number of deaths from pancreatitis in Jiangsu in 2018 was as high as 36000,including 21000 males and 15000 females,and the mortality rate was as high as 50.00%.In 2010 and 2018,the changes of DALY rate(325.6%),YLL rate(26.2%),and YLD rate(106.2%)of pancreatitis in Jiangsu were all higher than the global changes(-3.2%,-5.8%,and 32.6%).After being standardized by age,compared with that in 2010,the standardized YLD rate in Jiangsu increased by 21.6%,while the global standardized YLD rate dropped by 1.1%;the standardized YLL rate of pancreatitis in Jiangsu and the world both decreased as much as each other;compared with that in 2010, the DALY rate in Jiangsu decreased by -25.4%,and the global standardized DALY rate by 28.6%. Conclusions Compared with that in 2010, theburden of pancreatitis in Jiangsu in 2018 was getting heavier and higher than the global averagelevel. Clinical intervention should be carried out through various ways to reduce the burden ofpancreatitis on the family and society as much as possible.