丹参多酚酸盐辅助治疗不稳定型心绞痛患者的疗效评价

Evaluation of the efficacy of salvianolate adjuvant therapy in patients with unstable angina pectoris

目的探讨丹参多酚酸盐辅助治疗不稳定型心绞痛(unstable angina pectoris,UAP)对患者症状改善及心肌损伤标志物的影响。方法研究对象为UAP患者,采用随机数字表法将102例患者分为观察组和对照组,各51例。对照组应用常规西药治疗,观察组在对照组治疗的基础上应用丹参多酚酸盐,均持续治疗7 d。分析并比较2组患者治疗后的临床效果、治疗前后的心绞痛发作情况、血细胞比容、纤维蛋白原(fibrinogen,FIB)、凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)、磷酸肌酸激酶(creatine kinase,CK)、降钙素原(procalcitonin,PCT)、乳酸脱氢酶(lactate dehydrogenase,LDH)、磷酸肌酸激酶同工酶(creatine kinase-MB,CK-MB)、氨基末端脑钠肽前体(N-terminal pro-brain natiuretic peptide,NT-proBNP)水平及治疗期间的安全性。结果治疗后,观察组临床总有效率高于对照组;与治疗前比较,治疗后2组患者的心绞痛周发作次数、ST段下降幅度、血细胞比容、血浆FIB及血清hs-CRP、IL-6、PCT、LDH、CK-MB、CK和NT-proBNP水平均降低,且观察组均低于对照组;治疗后2组患者的心绞痛持续时间缩短,且观察组短于对照组;治疗后2组患者PT、TT延长,且观察组长于对照组,P<0.05;2组患者治疗期间的不良反应均不明显。结论丹参多酚酸盐辅助治疗UAP有利于改善患者的临床症状及机体凝血功能,心肌损伤程度明显减轻,同时对炎症反应有抑制作用,安全性高。

Objective To study the efficacy of salvianolate adjuvant therapy on symptom improvement and myocardial injury markers in patients with unstable angina pectoris(UAP).Methods 102 UAP patients were grouped into observation group(51 cases)and control group(51 cases)according to the random number table method.The control group was treated with the conventional western medicine,and the observation group was treated with salvianolate on the basis of the control group.The both groups were given continuous treatment for 7 days.The clinical effect after treatment,angina attack,hematocrit,fibrinogen(FIB),prothrombin time(PT),thrombin time(TT),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),creatine kinase(CK),procalcitonin(PCT),lactate dehydrogenase(LDH),creatine kinase-MB(CK-MB),N-terminal pro-brain natiuretic peptide(NT-proBNP)and safety during treatment of 2 groups of patients before and after treatment were analyzed and compared.Results After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group.Compared with before treatment,the number of seizures,ST segment decline,hematocrit,plasma FIB and serum hs-CRP,IL-6,PCT,LDH,CK-MB,CK and NT-proBNP levels in the 2 groups showed a downward trend,and the observation group was lower than the control group.After treatment,the duration of angina pectoris in the 2 groups shortened,and the observation group was shorter than the control group.After treatment,the PT and TT in the 2 groups prolonged,and the observation group was longer than the control group,P<0.05.There was no obvious adverse reaction in the 2 groups during treatment.Conclusion Salvianolate adjuvant therapy for UAP is beneficial to improve the clinical symptoms and coagulation function of patients.The degree of myocardial injury significantly reduced,and at the same time have inhibitory effect on inflammatory response with high safety.