巨噬细胞自噬与动脉粥样硬化关系的研究进展

Research progress on the relationship between macrophage autophagy and atherosclerosis

动脉粥样硬化(Atherosclerosis,AS)是一种与脂质代谢紊乱相关的慢性炎症性血管疾病,被认为是缺血性心脑血管疾病(Ischemic cardio/cerebrovascular disease,ICVD)的主要病理基础。自噬是一种自我保护的细胞分解代谢途径。越来越多的研究表明,巨噬细胞自噬在动脉粥样硬化中发挥着重要作用。本综述主要讨论了巨噬细胞自噬与动脉粥样硬化的关系以及靶向自噬过程治疗动脉粥样硬化的研究进展。

Atherosclerosis(AS)is a classic chronic inflammatory vascular disease.It is considered as the main pathological basis of ischemic cardio/cerebrovascular disease(ICVD).Autophagy is a self-protecting cellular catabolic pathway.A growing number of researches suggests that in AS,macrophage autophagy plays an important role in promoting cholesterol outflow,inhibiting inflammatory signaling and apoptosis.This review mainly discusses the relationship between macrophage autophagy and atherosclerosis,and the research progress of targeting the autophagy process in the treatment of atherosclerosis.