胶质细胞源性神经营养因子修饰的三种细胞在脊髓损伤中的研究

Research on the three kinds of cells modified by GDNF in spinal cord injury

近年来脊髓损伤的发病人数逐年增加,该损伤预后较差,给患者家庭及社会带来沉重负担。目前脊髓损伤修复的最大难题是轴突的再生和髓鞘形成。相关研究证实,胶质细胞源性神经营养因子(Glial cell line-derived neurotrophic factor,GDNF)基因修饰的骨髓间充质干细胞、脂肪间充质干细胞和雪旺细胞移植到损伤脊髓中,能够显著改善神经元再生困难、局部生长因子匮乏、损伤轴突脱髓鞘化和胶质疤痕形成等,促进脊髓损伤修复。本文就骨髓间充质干细胞、脂肪间充质干细胞和雪旺细胞进行胶质细胞源性神经营养因子修饰后在脊髓损伤中的有关作用进行综述。

The incidence of spinal cord injury is increasing in recent years.The prognosis of spinal cord injury is poor and it brings a heavy burden to families of patients and society.The most difficult problem in the repair of spinal cord injury is axon regeneration and myelin sheath formation.Relevant studies verified that the transplantation of bone marrow-derived mesenchymal stem cells,adipose derived mesenchymal stem cells and schwann cells modified by glial cell line-derived neurotrophic factor(GDNF)in injured spinal cord can significantly improve the difficulties of neuron regeneration,deficiency of local growth factors,demyelination of injured axons and formation of glial scar,and then promote the repair of spinal cord injury.The role of the three kinds of cells modified by GDNF in spinal cord injury is reviewed.