摘要
类器官系统作为内耳的体外模型之一,可以在体外模拟内耳相关的缺陷疾病,帮助识别新的保护或再生药物及开发新的基因疗法,是未来临床应用的潜在工具。干细胞技术和类器官培养技术的进步为内耳疾病建模和开发听力损失的个性化疗法提供了独特的机会。本文主要综述近十年来内耳类器官的构建完善以及应用的进展。
The organoid system is one of the in vitro models of the inner ear.It can simulate inner ear-related defects and assist in the identification of new protective or regenerative drugs as well as development of novel gene therapies.It is potential tools for future clinical applications.The advancements in stem cell technology and organoid culture techniques provide a unique opportunity for modeling inner ear diseases and developing personalized therapies for hearing loss.This article primarily reviews the progress in the construction and application of inner ear organoids over the past decade.
作者
古兴亮
林昭锦
齐洁玉
柴人杰
GU Xing-liang;LIN Zhao-jin;QI Jie-yu;CHAI Ren-jie(State Key Laboratory of Bioelectronics,Department of Otolaryngology,Head and Neck Surgery,The affiliated Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Provincial High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China;School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510000,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China;Department of Otolaryngology,Head and Neck Surgery,Sichuan Academy of Medical Sciences&Sichuan Provincial People′s Hospital,Chengdu 610072,China;Institute for Stem Cell and Regeneration,Chinese Academy of Science,Beijing 100101,China;Beijing Key Laboratory of Neural Regeneration and Repair,Capital Medical University,Beijing 100069,China)
出处
《实用医院临床杂志》
2023年第4期1-4,共4页
Practical Journal of Clinical Medicine
基金
国家重点研发计划(编号:2021YFA1101300,2020YFA0112503)
国家自然科学基因重点项目和面上项目(编号:82030029,81970882)。
