肿瘤标志物和细胞因子联合检测对早期肺腺癌的诊断价值

Diagnostic value of combined determination of tumor markers and cytokines in early stage lung adenocarcinoma

目的探讨多种肿瘤标志物和细胞因子联合检测对早期肺腺癌的诊断价值。方法收集四川省人民医院胸外科住院并明确诊断为肺腺癌的患者308例(肺腺癌组),肺良性疾病患者84例(肺良性疾病组),分析患者肿瘤标志物和细胞因子与肺腺癌的关系,筛选可预测肺腺癌的指标,计算曲线下面积及相应的灵敏度、特异度。结果肺腺癌组和肺良性疾病组在肿瘤家族史、结节位置和结节大小方面比较差异有统计学意义(P<0.05),肺腺癌组IL-2、IL-10和CEA表达水平高于肺良性疾病组(P<0.05)。IL-2、IL-10和CEA是可预测早期肺腺癌的独立危险因素(P<0.05),IL-2+IL-10+CEA联合检测临床诊断价值最高(P<0.05)。结论IL-2、IL-10和CEA为诊断早期肺腺癌的独立危险因素,联合检测IL-2+IL-10+CEA在早期肺腺癌的临床诊断中具有一定价值。

Objective To explore the diagnostic value of combined multiple tumor markers and cytokines in early stage lung adenocarcinoma.Methods Three hundred and eight patients with lung adenocarcinoma diagnosed at Department of Thoracic Surgery of Sichuan Provincial People′s Hospital were collected as a lung adenocarcinoma group.Another 84 patients with benign lung diseases were collected as a control group.The association between the tumor markers and cytokines and the lung adenocarcinoma was explored.The predictive markers for lung adenocarcinoma were screened by combined analysis.The area under the ROC curve and the corresponding sensitivity and specificity were calculated.Results There were significant differences in tumor family history,nodule location and nodule size between the lung adenocarcinoma group and the control group(P<0.05).The levels of interleukin-2(IL-2),IL-10 and carcinoembryonic antigen(CEA)in the lung adenocarcinoma group were higher than those in the control group.IL-2,IL-10 and CEA were independent risk factors for predicting early stage lung adenocarcinoma(P<0.05).Combination of IL-2,IL-10 and CEA had the highest diagnostic value for predicting lung adenocarcinoma(P<0.05).Conclusions IL-2,IL-10 and CEA are inde-pendent risk factors for the diagnosis of early stage lung adenocarcinoma.The combined determination of IL-2+IL-10+CEA has certain value in the clinical diagnosis of early stage lung adenocarcinoma.