灯盏花素通过抑制NF-κB信号通路对脓毒症急性肺损伤患者的影响

Effects of breviscapine on sepsis-induced acute lung injury by inhibiting the NF-κB signaling pathway

目的探讨灯盏花素经核转录因子-κB(NF-κB)信号通路对脓毒症急性肺损伤(ALI)患者的影响。方法选择医院重症监护病房收治的120例脓毒症合并急性肺损伤患者作为研究对象,依随机对照原则分为对照组和灯盏花素组,各60例。对照组按照指南标准治疗,灯盏花素组在对照组治疗基础上给予灯盏花素注射液辅助治疗,2组均以连续治疗10 d为1疗程。结果治疗10 d后,灯盏花素组总有效率为85%,显著高于对照组的68.33%(P<0.05);与治疗前比较,治疗10 d后2组患者血清NF-κB、IL-6和TNF-α指标,Murry肺损伤评分均明显下降(均P<0.05),且灯盏花素组明显低于对照组(均P<0.05);与治疗前比较,治疗10 d后2组Pa O2/Fi O2明显升高(P<0.05),且灯盏花素组明显高于对照组(P<0.05)。治疗期间2组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论灯盏花素可能通过抑制NF-κB信号通路,减轻脓毒症急性肺损伤患者的炎症水平,发挥肺保护作用。

Objective To explore the effects of breviscapine on sepsis-induced acute lung injury(ALI)through the nuclear factor-kappa B(NF-κB)signaling pathway and to reveal its possible mechanism.Methods A total of 120 patients with sepsis combined with ALI admitted to the intensive care unit of the hospital were selected as the research subjects,and they were divided into a control group(n=60)and a breviscapine group(n=60)according to the randomized control principle.The control group was treated according to the guideline standard,while the breviscapine group was additionally given a breviscapine injection based on the control group.Both groups were treated for 10 days as a course of treatment.Results After 10 days of treatment,the total effective rate of the breviscapine group(85%)was significantly higher than that of the control group(68.33%)(P<0.05).Compared with before treatment,the Murry lung injury scores,serum NF-κB,IL-6 and TNF-αindexes were significantly decreased in the two groups after 10 days of treatment(all P<0.05),and the above indicators in the breviscapine group were all significantly lower than those in the control group(P<0.05).Compared with before treatment,the PaO2/FiO2 was significantly increased in the two groups after 10 days of treatment(P<0.05),and the breviscapine group was significantly higher than the control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups during treatment(P>0.05).Conclusion Breviscapine may reduce the inflammation level in patients with acute lung injury caused by sepsis by inhibiting the NF-κB signaling pathway and play a role in the lung protection.