基于聚类分析与贝叶斯网络的惊恐障碍中医证候规律探索

Exploration of traditional Chinese medicine syndrome discipline of panic disorder based on Cluster analysis and Bayesian network

目的探索惊恐障碍的中医证候规律。方法使用标准化的中医证候调查表采集193例符合惊恐障碍诊断标准的患者的四诊信息,并进行频率分析、聚类分析、贝叶斯网络分析,结合文献资料、专家意见判定证型分布。结果193例惊恐障碍患者的中医证型主要包括心脾两虚(33.68%)、心肾不交(26.94%)、心胆气虚(16.06%)、脾肾两虚(12.95%)、脾胃湿热(10.36%)。结论除脾胃湿热外,虚性证型在惊恐障碍中较为突出,包含心肾不交、心脾两虚、脾肾两虚、心胆气虚四类;且证型大多与“心”关联,涉及心肾不交、心脾两虚、心胆气虚三证。

Objective To explore the traditional Chinese medical(TCM)syndrome discipline of panic disorder.Methods A standardized TCM syndrome inventory was used to collect symptoms based on the four diagnostic methods from 193 patients who met the criteria for panic disorder.Frequency analysis,Cluster analysis,and Bayesian network were performed,and relevant literatures and expert opinions were incorporated to determine the distribution of syndrome types.Results The syndrome types of 193 patients with panic disorder involve the syndrome of deficiency of both heart and spleen(33.68%),syndrome of disharmony between heart and kidney(26.94%),syndrome of qi deficiency of heart and gallbladder(16.06%),syndrome of spleen-kidney deficiency(12.95%),syndrome of dampness-heat of spleen and stomach(10.36%).Conclusions In addition to the syndrome of dampness-heat of spleen and stomach,syndrome types of deficiency seem to be more prominent in panic disorder,comprising syndrome of disharmony between heart and kidney,syndrome of deficiency of both heart and spleen,syndrome of spleen-kidney deficiency,syndrome of qi deficiency of heart and gallbladder.Also,most of the syndrome types are heart-related,involving syndrome of disharmony between heart and kidney,syndrome of deficiency of both heart and spleen,syndrome of qi deficiency of heart and gallbladder.