聚乙醇酸的合成及其在生物医学领域的研究进展

Research Progress in Synthesis and Biomedical Applications of Poly(glycolic acid)

聚乙醇酸(PGA)是一种具有优异生物相容性的可降解高分子材料,被广泛应用于生物医用、包装及油气开采等领域。文章综述了PGA的合成方法,包括直接缩聚方法和开环聚合方法等。对比了乙交酯通过配位-插入聚合、阴离子聚合或阳离子聚合得到的聚乙醇酸的基本性能及反应机理。归纳总结了PGA应用于可吸收缝合线、骨折内固定、组织工程、药物递送和生物胶水等生物医学领域的加工方法、性能要求和效果,并对PGA在生物医学领域的应用发展进行展望。

Polyglycolic acid(PGA)is a biodegradable polymer material with excellent biocompatibility,which is widely used in biomedicine,packaging,oil and gas exploitation and other fields.The synthesis methods of PGA are reviewed,including direct polycondensation route and ring-opening polymerization route.The basic properties and reaction mechanism of polyglycolic acid obtained by coordination-insertion polymerization,anionic polymerization or cationic polymerization of glycolide are compared.The processing methods,performance requirements and effects of PGA in biomedical fields such as absorbable suture,fracture internal fixation,tissue engineering,drug delivery and biological glue were summarized,and the application and development of PGA in biomedical field are prospected.