卵巢癌中蛋白翻译后修饰的研究进展

Research Progress of Post-Translational Modification in Ovarian Cancer

近年卵巢癌的诊治虽已取得较大进展,但其5年生存率不足47%,积极探索新的治疗方法或新靶点十分必要。蛋白翻译后修饰(post-translational modification,PTM)是蛋白质功能调节的重要方式,通过对前体蛋白进行翻译后加工,改变蛋白质的理化性质、构象和结合能力,从而影响蛋白质的活性、稳定性和功能等方面。目前针对卵巢癌的研究主要集中在磷酸化、乙酰化、O-GlcNAc糖基化、S-棕榈酰化和泛素化等PTM,通过调节多种蛋白质的功能,调控相关信号通路或影响其下游分子的表达,影响卵巢癌细胞的增殖、侵袭、凋亡、耐药及化疗敏感性等。综述PTM在卵巢癌中的研究进展,以期为卵巢癌的精准靶向治疗提供新的理论依据。

Although great progress has been made in the diagnosis and treatment of ovarian cancer in recent years,the proportion of patients with the 5-year survival is still less than 47%.It is necessary to explore actively new treatment methods or new targets.Post-translational modification(PTM)is an important way to regulate protein function.It modifies the physical and chemical properties,conformation,and the binding ability of proteins through post-translational processing of precursor proteins,thereby affecting protein activity,stability and function.At present,the research on ovarian cancer mainly focuses on PTM such as phosphorylation,acetylation,O-GlcNAcylation,S-palmitoylation and ubiquitination,which affect the proliferation,invasion,apoptosis,drug resistance and chemotherapy sensitivity of ovarian cancer cells by regulating the function of a variety of proteins,regulating related signaling pathways or affecting the expression of downstream molecules.This review on the research progress of PTM in ovarian cancer may provide a new theoretical basis for the precise and targeted therapy of ovarian cancer.