经典瞬时受体电位通道在骨骼肌疾病中作用的研究进展

Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases

经典瞬时受体电位通道(TRPC)是位于细胞膜上的一类非选择性阳离子通道,对细胞正常的电生理活动具有重要的作用。病理状态下,TRPC对Ca^(2+)的选择性更高,它可破坏骨骼肌细胞内Ca^(2+)稳态,使其发生钙超载,进而发生多种骨骼肌疾病。研究TRPC通道在骨骼肌疾病中的作用与机制,有助于为该疾病治疗提供新思路。

Canonical transient receptor potential(TRPC)is a kind of non-selective cation channel located in the cell membrane,which plays an important role in electrophysiological activity of cells.Under pathological conditions,TRPC channels are more selective for Ca^(2+),which will break the Ca^(2+)homeostasis in skeletal muscle cells and lead to calcium overload and subsequent occurrence of a variety of skeletal muscle diseases.To study the role and mechanism of TRPC channels in skeletal muscle diseases is helpful to provide new ideas for disease treatment.