靶向铁死亡治疗非酒精性脂肪性肝病的研究进展

Research progress of drugs targeting ferroptosis for the treatment of non-alcoholic fatty liver disease

铁死亡是一种铁依赖性的调节性细胞死亡形式,铁死亡通过铁过载、GPX4失活和脂质过氧化参与非酒精性脂肪性肝病(NAFLD)发病机制,药物靶向性抑制铁死亡可以缓解NAFLD的进展。抑制铁死亡有望成为治疗NAFLD的潜在新策略。

Emerging evidence indicates that ferroptosis,an iron-dependent form of regulated cell death,plays a critical role in the pathological progression of non-alcoholic fatty liver disease(NAFLD).Ferroptosis involves in the pathogenesis of NAFLD and drugs targeting at ferroptosis by its inhibitors can alleviate the progression of NAFLD both in vitro and in vivo.Pharmacological inhibition of ferroptosis might be a potential strategy of NAFLD treatment.