HIV动物模型在毒品滥用研究中的应用

Application of a HIV animal model in drug abuse research

目前,毒品滥用及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染的共病问题备受关注。毒品滥用是HIV传播的促发因素之一,其同样可加重HIV感染者中枢神经系统的病毒载量水平和加速HIV相关神经认知障碍(HIV-associated neurocognitive disorders,HAND)的疾病进展速度。本文着重介绍了目前常用的HIV感染相关动物模型,如非人灵长类动物、啮齿类动物及猫科动物,分析了其局限性和优势性,并对HIV感染相关动物模型在毒品滥用研究中的应用进行了综述。

The comorbidity of drug abuse and human immunodeficiency virus(HIV)infection has attracted much attention.Drug abuse is a promoter of HIV transmission.It also aggravates the viral load in the central nervous system and accelerates the progression of HIV-associated neurocognitive disorders.This article focuses on the commonly used animal models related to HIV infection,such as non-human primates,rodents,and felines,analyzes their limitations and advantages,and summarizes the latest research progress of animal models related to HIV infection in drug abuse.