摘要
金黄地鼠被用于研究人类相关疾病已有60多年,广泛应用于新型冠状病毒、代谢性疾病发病机制、疫苗和治疗性药物效果评价的研究中。WTO规定用于疫苗生产和检定的金黄地鼠必须达到无特定病原体(specific pathogen free,SPF)级,而目前国内使用的多为普通级。通过生物净化提升金黄地鼠种群微生物等级势在必行。本文概述了金黄地鼠在新型冠状病毒、代谢性疾病研究中的应用及相关生物净化技术工作进展。
The golden hamster has been used as an animal model to study human diseases for more than 60 years,such as COVID-19 and metabolic diseases,and for safety evaluation of vaccines and therapeutic drugs.In accordance with the regulations of the WTO,golden hamsters used for vaccine production and verification must have a microbe control grade of specific pathogen free,but conventional animals are commonly used domestically.Therefore,it is imperative to improve the microbial grade of golden hamsters through sterile Cesarean section.In this review,we broadly discuss the applications of golden hamsters in the study of COVID-19 and metabolic diseases,and the research progress of sterile Cesarean section.
作者
郭亚茜
杜晓鹏
朱华
GUO Yaxi;DU Xiaopeng;ZHU Hua(Institute of Laboratory Animal Sciences,CAMS&Comparative Medicine Center,Peking Union Medical Collage,PUMC,NHC Key Laboratory of Human Disease Comparative Medicine,Beijing 100021,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第5期676-682,共7页
Acta Laboratorium Animalis Scientia Sinica
基金
中国医学科学院医学与健康科技创新工程项目(2022-12M-1-020)。
关键词
金黄地鼠
生物净化
动物模型
golden hamster
biological purification
animal models
