Combating mitochondrial toxicity: looking at the past and where to go

Mitochondria are the main sources of intracellular energy and reactive oxygen species(ROS),which play an important role in the regulation of cell survival and death under pathological conditions.Mitochondria are important targets of drug toxicity[1].Some antiviral drugs,antitumor drugs and antibiotics can significantly induce mitochondrial damage in target organs such as the liver and heart[2].Drug-induced mitochondrial damage may involve multiple pathways and mechanisms.