热量限制对衰老及老年相关疾病影响的研究进展

Research Progress of the Influence of Caloric Restriction on Senility and Geriatric Diseases

衰老是随着增龄出现的组织器官功能性衰退过程,伴随着多种老年相关性疾病的发生。热量限制(CR)作为一种重要的饮食干预方式,参与了衰老过程,并且可以明显改善老年高血压、糖尿病、阿尔茨海默病、肌少症以及衰弱等多种老年相关疾病的发生及发展。本文综述CR对衰老和老年相关疾病影响的研究进展,为CR的临床应用和推广提供依据。

Senescence is a physiological process characterized by a progressive decline in tissue and organ function as individuals age.With advancing age,the occurrence of various age-related diseases often coincides with senescence.Caloric restriction(CR),a dietary intervention,has been closely associated with senescence and has demonstrated remarkable potential in the prevention and amelioration of numerous age-related conditions,such as hypertension,diabetes mellitus,Alzheimer's disease,sarcopenia,and asthenia.This comprehensive literature review explores the profound impact of CR on senescence and age-related diseases,aiming to provide robust evidence to support the clinical application of CR as a promising therapeutic strategy.