肠道菌群对男性不育症影响的研究进展

Research progress on the relationship between gut microbiota and male infertility

近年来育龄男性生育力下降,不育症已成为亟待解决的全球性问题。现有证据表明肠道菌群对男性生殖健康有重要影响,肠道菌群紊乱可通过诱导炎症反应、代谢紊乱、内分泌紊乱等机制影响精子发生。本文系统回顾了该领域的相关研究进展,重点从肠道菌群与精子发生、肠道菌群与性激素代谢、粪菌移植及膳食调节对生殖功能的影响等方面阐述肠道菌群紊乱对男性生殖能力的影响,探讨肠道菌群与男性不育症的未来研究方向。

With the decline in male fertility in recent years,infertility has become an urgent global problem to be solved.Existing evidence shows that gut microbiota has an important impact on male reproductive health,and gut microbiota disorder can affect spermatogenesis by inducing inflammation,metabolic disorder and endocrine disruption.This paper systematically reviews the relevant research progress in this field,focusing on the impact of gut microbiota disorder on male reproductive ability from the aspects of gut microbiota and spermatogenesis,gut microbiota and sex hormone metabolism,effects of fecal microbiota transplantation and dietary regulation on male reproductive function,and discusses the future research directions of gut micro-biota and male infertility.