氟比洛芬酯联合低分子肝素钠治疗对老年髋关节置换患者VAS评分及氧化应激反应的影响

Effect of flurbiprofen axetil combined with low molecular weight heparin on VAS score and oxidative stress response in elderly patients with hip replacement

目的探讨氟比洛芬酯联合低分子肝素钠治疗对老年髋关节置换患者VAS评分及氧化应激反应的影响。方法选取我院2018年6月至2019年6月收治的204例因股骨头坏死行髋关节置换术的老年患者,采用数字随机表法将所有患者分为两组。观察组102例采用氟比洛芬酯,对照组102例采用舒芬太尼与100 mL生理盐水混合式镇痛泵,两组术后均联合低分子肝素钠治疗。观察两组患者视觉模拟评分(VAS评分);观察两组患者整个治疗过程中氧化应激反应指标NE、GSH⁃Px、AngⅡ的水平;对比术后并发症发生率情况以及治疗满意度情况。结果观察组患者术后12、24 h的VAS评分指数明显低于对照组患者,差异有统计学意义(P<0.05);观察组患者术后NE,AngⅡ水平值上升均显著低于对照组患者,GSH⁃Px值下降显著低于对照组患者,差异有统计学意义(P<0.05);两组患者术后并发症发生率对比,差异无统计学意义(P>0.05)。结论氟比洛芬酯联合低分子肝素钠治疗老年髋关节置换患者,可以更有效起到镇痛的作用,明显降低患者VAS评分,维持机体正常氧化应激反应水平,降低术后并发症的发生情况,提高治疗满意度,值得临床推广应用。

Objective To explore the effect of flurbiprofen axetil combined with low molecular weight heparin sodium on VAS score and oxidative stress response in elderly patients with hip replacement.Methods A total of 204 elderly patients with osteonecrosis of the femoral head in our hospital from June 2018 to June 2019 were selected and all the patients were divided into two groups by digital random table method.The study group(102 patients)was treated with flurbiprofen axetil combined with low molecular weight heparin sodium,and the control group(102 patients)received sufentanil mixed with 100 ml normal saline.The visual analogue score,VAS score index,and levels of oxidative stress reaction index NE,GSH PX and angⅡduring the treatment were observed in the two groups.The incidence of postoperative complications and treatment satisfaction were compared.Results The VAS score was significantly lower in the study group than in the control group at 12/24 h(P<0.05);level of increases in NE and angⅡin the study group was significantly lower than that in the control group,and a decline in GSH PX value was significantly lower than that in the control group(P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusions Flur⁃biprofen axetil combined with low molecular weight heparin sodium for elderly patients with hip replacement plays an analgestic role more effectively.This therapy significantly reduces the VAS scores,maintains the normal level of oxidative stress reaction,lowers the incidence of postoperative complications,and improves treatment satisfaction,which is worthy of clinical application.