老年高血压人群身高与新发脑梗死关系

The association between the body height and novel cerebral infarction in the elderly with hypertension

目的探讨老年高血压人群身高与新发脑梗死的关系。方法以开滦研究人群为对象,采取前瞻性队列研究方法,纳入9574例老年高血压患者,以首次发生脑梗死为终点事件。依据观察对象身高值进行四分位分组,用寿命表法分别计算不同身高组累积终点事件发生率,并分别采用Cox比例风险模型分别分析身高对脑梗死风险的影响。结果在平均(9.3±2.7)年的随访期间内,共新发脑梗死885例。以身高<161.5 cm(Q1组)组为对照,多因素Cox比例风险回归模型分析显示161.5~166.0 cm(Q2组)、166.0~170.0 cm(Q3组)和≥170.0 cm(Q4组)模型二中新发脑梗死事件风险比[HR(95%CI)]分别为0.95(0.78~1.16)、1.00(0.81~1.23)、0.71(0.56~0.90);模型三中各组发生脑梗死HR值(95%CI)分别为1.01(0.81~1.24)、1.10(0.89~1.36)、0.76(0.60~0.96);模型四中各组发生脑梗死HR值(95%CI)分别为0.98(0.79~1.21)、1.06(0.85~1.33)、0.72(0.56~0.93)。结论在老年高血压人群中较高的身高与新发脑梗死风险降低相关。

Objective The study aimed to investigate the association between the body height and the risk of novel cerebral infarction in the elderly with hypertension.Methods 9574 elderly hypertension patients were monitored in this cohort research based on the Kailuan research group for cerebral infarction.Patients were categorized into quartile groups.The life table method was used to calculate the cumulative incidences of outcomes in different groups.Cox proportional hazards model was used to analyze hazard ratios(HR)with the corresponding 95%confidence interval(CI)of outcomes in different groups.Results Compared to the body height≤161.5 cm(Q1)group,the multivariate Cox proportional hazard regression model showed that the hazard ratio[HR(95%CI)]for cerebral infarction in model 2 were 0.95(0.78~1.16),1.00(0.81~1.23)and 0.71(0.56~0.90)respectively in 161.5~166.0 cm(Q2),166.0~170.0 cm(Q3)and≥170.0 cm(Q4);in model 3,cerebral infarction[HR(95%CI)]in each group were 1.01(0.81~1.24),1.10(0.89~1.36)and 0.76(0.60~0.96)respectively;in model 4 were 0.98(0.79~1.21),1.06(0.85~1.33)and 0.72(0.56~0.93),respectively.Conclusion In the elderly with hypertension,a taller body height is connected with a decreased incidence of cerebral infarction.