m6A修饰在胶质瘤中的研究进展

Research progress of m6A modification in glioma

胶质瘤是中枢神经系统肿瘤,主要来源于神经胶质细胞,目前临床上以手术切除辅以放疗、化疗、电场治疗等综合疗法,但其很难彻底切除,且很容易从原发肿瘤上脱离并穿过脑组织,导致患者复发,甚至死亡。N6⁃甲基腺嘌呤(m6A)基因修饰作为mRNA转录后修饰广泛分布于真核细胞中,其修饰过程由一系列的蛋白质完成,根据蛋白质在甲基化过程中作用的不同,分为甲基转移酶、去甲基酶和结合蛋白。动态和可逆的m6A修饰影响胶质瘤的发生发展、侵袭转移、血管生成等生物学行为,此外,在胶质瘤的诊疗以及预后评估等方面发挥临床作用。本文将从m6A修饰在胶质瘤中的生物学作用和应用等方面进行综述,为胶质瘤的治疗提供一种新思路。

Glioma is a tumor of the central nervous system,mainly derived from glial cells.Currently,surgical resection combined with radiotherapy,chemotherapy,electric field therapy and other comprehensive thera⁃pies are used in clinical practice.However,glioma is difficult to be completely removed,and it is easy to escape from the primary tumor and pass through the brain tissue,leading to relapse and even death of patients.N6⁃methyl⁃adenine(m6A)gene modification is widely distributed in eukaryotic cells as post⁃transcriptional modification of mRNA.The modification process is completed by a series of proteins,which can be divided into methyltransferase,demethylase and binding protein according to the different roles of proteins in the methylation process.Dynamic and reversible m6A modification affects the biological behaviors of glioma,such as the occurrence and develop⁃ment,invasion and metastasis,and angiogenesis.In addition,it plays a clinical role in the diagnosis,treatment and prognosis assessment for glioma.This article reviews the biological effects and applications of m6A modification in glioma,providing a new idea for the treatment of glioma.