肝硬化腹水与肠黏膜屏障功能关系研究进展

Research progress on the relationship between cirrhotic ascites and intestinal mucosal barrier function

腹水是失代偿期肝硬化常见的并发症之一。腹水出现后病死率显著增高。腹水产生的机制较为复杂,往往是多种因素共同导致的。近年来随着高通量测序技术及临床检测技术的发展,肝硬化患者肠道菌群及炎症反应的研究逐渐深入,其改变均会导致肠黏膜通透性增高,增加自发性细菌性腹膜炎的发病率,导致肝硬化腹水的发生发展。本文对肝硬化腹水与肠黏膜屏障功能的关系以及肝硬化腹水常规治疗对肠道菌群及炎症因子的影响进行综述,以期为进一步探索肝硬化腹水的发病机制及治疗提供思路。

Ascites is one of the common complications of clinically decompensated liver cirrhosis.The fatality rate increased greatly after the appearance of ascites.The mechanism of ascites is more complicated,and it is often caused by a combination of multiple factors.In recent years,with the development of high-throughput sequencing technology and clinical detection technology,the study of intestinal flora and inflammatory response in patients with liver cirrhosis has gradually deepened.All changes will increase intestinal mucosal permeability and increase spontaneous bacterial peritonitis.The incidence of cirrhosis leads to the development of ascites in liver cirrhosis.This article reviewed the relationship between cirrhotic ascites and intestinal mucosal barrier function and the influence of conventional treatment of cirrhotic ascites on intestinal flora and inflammatory factors,to provide some ideas for further exploring the pathogenesis and treatment of cirrhotic ascites.