纳米分子影像学在静脉血栓栓塞中的诊疗研究进展

Research progress of nanomolecular imaging in diagnosis and treatment of venous thromboembolism

静脉血栓栓塞(VTE)包括肺栓塞(PE)和深静脉血栓形成(DVT),是全世界最常见的心血管疾病之一,造成了巨大的社会经济负担。临床常以抗血栓治疗为主,由于抗血栓治疗与凝血及溶血系统有关,因此这种治疗方式有极高的出血风险,需要对病程进展进行严格的监控,但现有的手段不能完全满足未来临床精准医疗的需要。分子影像学能反映疾病分子层面的信息,通过影像手段,对血栓靶向纳米探针进行定量监测,对疾病的亚型精准诊断并提供个性化治疗。本综述介绍了近年来纳米分子影像学在VTE中的诊疗研究进展,有望为VTE的诊治提供新的思路。

Venous thromboembolism(VTE),including pulmonary embolism(PE)and deep vein thrombosis(DVT),is considered as one of the most common cardiovascular diseases in the world,causing a huge social and economic burden.Despite the predominant role in the treatment of VTE,anti-thrombotic therapy has an extremely high risk of bleeding due to its association with blood coagulation and hemolysis system.Therefore,strict monitoring should be performed during the disease progression.However,the existing approaches can not fully meet the needs of precision medicine.Molecular imaging can reflect the disease information at the molecular level.Quantitative monitoring on thrombus-targeted nanoprobes through imaging approaches can accurately diagnose disease subtypes and provide personalized treatment.This article reviews the research progress of nanomolecular imaging in the diagnosis and treatment of VTE in recent years,which is expected to provide new ideas for the diagnosis and treatment of VTE.