龙胆泻肝汤加减治疗湿热蕴结型慢性盆腔炎的疗效分析

Analysis of curative effect of Longdan Xiegan decoction on chronic pelvic inflammatory disease with dampness and heat accumulation

目的分析湿热蕴结型慢性盆腔炎(CPID)采用龙胆泻肝汤加减治疗的临床疗效。方法选取62例湿热蕴结型CPID患者,根据随机数字表法分为甲组与乙组,每组31例。甲组采用常规西药治疗,乙组在甲组基础上联合龙胆泻肝汤加减治疗。对比两组治疗效果、1年内复发率、中医症状评分及炎性因子指标。结果乙组治疗有效率96.77%高于甲组的74.19%,1年内复发率0低于甲组的19.35%,差异有统计学意义(P<0.05)。乙组患者中医症状评分低于甲组,差异有统计学意义(P<0.05)。治疗前,两组肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)及C-反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组TNF-ɑ、IL-6及CRP水平均低于治疗前,且乙组明显低于甲组,差异具有统计学意义(P<0.05)。结论龙胆泻肝汤加减治疗湿热蕴结型CPID患者疗效显著,具有临床推广价值。

Objective To analyze the clinical effect of Longdan Xiegan decoction in the treatment of damp-heat chronic pelvic inflammatory disease(CPID).Methods 62 patients with damp-heat accumulation type CPID were selected and divided into group A and group B according to random number table method,with 31 cases in each group.Group A was treated with conventional western medicine,group B was treated with Longdan Xiegan decoction on the basis of group A.The therapeutic effect,recurrence rate within 1 year,TCM symptom score and inflammatory factor index were compared between the two groups.Results The effective rate of group B was 96.77%higher than that of group A(74.19%),and the recurrence rate within 1 year was 0 lower than that of group A(19.35%),and the difference was statistically significant(P<0.05).The TCM symptom score of group B was lower than that of group A,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),interleukin-4(IL-4)and C-reactive protein(CRP)between 2 groups(P>0.05).After treatment,the levels of TNF-alpha,IL-6 and CRP in both groups were lower than before,and group B was significantly lower than group A,with statistical significance(P<0.05).Conclusion Longdan Xiegan decoction has significant curative effect in the treatment of damp-heat accumulation type CPID patients,and has specific clinical promotion value.